08/28/2008
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Smell 101 Lessons

Lesson #1
How Does the Sense of Smell Work?

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Lesson #2
Smell Loss

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Lesson #3
I Know What I Like
Understanding Odor Preferences


Web Site Links

Cardiff University - Tim Jacobs
Tim Jacobs’ site at Cardiff University’s website provides a wealth of information about how the sense of smell works and other related topics including: smell disorders, pheromones, cell physiology, smell and the brain and even a short “smell quiz.”

Howard Hughes Medical Institute (HHMI)
This site is chock full of groundbreaking information about the sense of smell and how it works In humans and animals.  We suggest the following features in particular:
 
Seeing, Hearing and Smelling the World
– This is an excellent online publication that includes chapters on “The Vivid World of Odors,” “ Finding the Odorant Receptors.” “ How Rats and Mice – and Probably Humans – Recognize Odors,” “The Memory of Smells.”

Representations of Olfactory Information in the Brain”– Report on the work of Dr. Richard Axel that discusses how receptors and olfactory neurons work with the brain to form a topographic map of olfactory information.

“Researchers Discover How Mammals Distinguish Different Odors” and “Researchers Discover Precise Olfactory Map”– Reports on how researchers have solved the puzzle of how the nose can discriminate an estimated 10,000 different odors.

Leffingwell & Associates
The Leffingwell website offers a downloadable report in PDF format that provides a comprehensive status report on our current understanding of olfaction and provides in detail the possible molecular interactions involved.

University of California, Berkeley
This link to the CNN.com site features an article about research done at the University of California, Berkeley that demonstrates that the human brain can be trained to detect new smells. The results shed light on how the brain adapts to new stimulation and how potentially it might recover from injury or damage. See link in our Scientific Articles section for reference to original article that appeared in the journal Nature.

University of California, Irvine
The website posted by Dr. Michael Leon’s lab at the University of California, Irvine contains the Glomerular Activity Response Archive for the Rat Olfactory Bulb. The archive contains the averaged activity maps generated from the glomerular response to selected odorants in rat olfactory bulbs, as assessed by [14]-C 2-deoxyglucose uptake. These response profiles may be searched either by the Chemical Abstracts Service Registry Number (CAS number) of the odorants, odorant name, chemical formula, or chemical features. A detailed description of the procedure used to generate the response maps is provided, along with templates for duplication of the technique. Finally, a profile of identified olfactory bulb glomerular response modules is provided

University of Washington – Dr. Eric Chudler
Dr. Eric H. Chudler’s web site at the University of Washington provides an overview of the cranial nerves and an informative section on the olfactory system.

Wayne Statue University
The Wayne State University site has course outline material on smell, including anatomy, odor stimuli, smell classifications, and olfactory damage.

Yale University School of Medicine
A description of the anatomy of the cranial nerves including the olfactory nerve, which is responsible for odor perception can be found at the Yale University website. Excellent graphics let you follow projections of the olfactory nerve into the brain.

Yale University – Sense Lab
The SenseLab web site is a collaboration among many research groups at Yale University. It includes a searchable database of the gene sequences for olfactory receptor proteins in humans and other animals.

Additional Resources:

SOSI Sponsored Research

Web Site Links

Suggested Reading

Glossary of Smell Disorders